Nws tau tshawb pom tias α-solanine, ib qho tshuaj lom muaj nyob hauv cov nroj tsuag qos, yog los ntawm cov iab-saj tsis qab-tomatine, uas muaj nyob hauv cov txiv lws suav, kev tshaj tawm los ntawm Kobe University tau tshaj tawm thaum lub Peb Hlis 26. Cov kws tshawb nrhiav los ntawm Kyoto University , RIKEN Center for Sustainable Resource Science thiab Osaka University, kuj yog ib feem ntawm txoj haujlwm tshawb nrhiav.
Cov kws tshawb nrhiav tau tshawb xyuas theα-solanine biosynthesis txoj hauv kev hauv cov nroj tsuag qos. Los ntawm kev siv genome editing, lawv tau cuam tshuam cov biosynthetic enzyme gene hauv qos kom nws tsis tuaj yeem tsim cov-solanine. Kev pub noj tom-tomatine rau qhov cuam tshuam ces ua rau lub cev hloov pauv kev hloov pauv rau cov solanidane compound, cov lus tshaj tawm
Lub 2-oxoglutarate dependant dioxygenase (DPS) gene uas tau hais tawm hauv cov qos yaj ywm thaum lub sijhawm hesis-solanine hluavtaws tau muab tso tawm. Rau kev tshawb nrhiav txuas ntxiv, cov kws tshawb fawb tsim cov nroj tsuag hloov kho uas DPS cov lus qhia tau tsom xam los ntawm RNA cuam tshuam.
"Cov solanidane ntau nyob hauv cov qos ntoo tau hloov pauv tau qis dua li pawg neeg tsis tau hloov, thiab spirosolanes sau ua ke sab hauv cov nroj tsuag tam sim ntawd solanidanes,"
Qhov kev ua si enzymatic ntawm DPS los ntawm kev tso cov protein thiab qhia rau lawv hauv E. coli tau ntsuas. Cov txiaj ntsig pom tau hais tias lub luag haujlwm tseem ceeb ntawm DPS nyob rau hauv spirosolane hloov mus rau hauv solanidane - ua pov thawj DPS yog qhov tseem ceeb enzyme lub luag haujlwm rau qhov kev hloov no.
Cov kev tshawb fawb pom tau hais tias cov qos yaj ywm tuaj yeem tsim cov sol-solanine, vim yog qhov tshwm sim ntawm DPS, uas yog lub luag haujlwm rau metabolically hloov spirosolane.
Nws paub tias txiv lws suav tseem muaj enzyme rau metabolizing spirosolanes. Qhov iab-saj-tomatine pom nyob rau hauv cov txiv lws suav tsis muaj dab tsi tab sis yog metabolized rau hauv cov mov, tsis muaj tshuaj lom esculeoside A ua cov txiv hmab txiv ntoo siav, cov ntawv tshaj tawm.
Cov qos yaj ywm tau sau npe rau cov khoom noj muaj txiaj ntsig zoo vim tias ntau ntau ntawm cov tshuaj lom sol-solanine tuaj yeem ua rau cov zaub mov raug mob .Txoj kev tshawb fawb no tau cia siab tias lawv tuaj yeem muab lub hauv paus rau yav tom ntej cov qos yam uas lub biosynthesis ntawm cov tshuaj lom cov tshuaj lom yog los ntawm kev tsom mus rau DPS gene Cov.
Qhov kev cia siab yog tias cov txiaj ntsig kev tshawb fawb no tuaj yeem siv rau hauv kev cog qoob loo qos yaj ywm los ua lub hauv paus rau kev tawm tsam nrog kev sib xyaw ntawm cov tshuaj lom, cov ntawv tshaj tawm.