Lavxias teb sab cov kws tshawb fawb los ntawm State Agrarian University ntawm Novosibirsk, uas ua ke nrog cov npoj yaig los ntawm UK, tau thawj zaug thaiv ib qho inhibitor uas ua rau cov kab mob ua rau cov kab mob tsis haum rau qhov kev txiav txim ntawm cov kab mob cab. Cov nceb no yog siv los ua lub hauv paus rau cov tshuaj tua kab tsuag, thiab cov txiaj ntsig los ntawm kev tshawb fawb yuav pab tsim kom muaj cov khoom siv tiv thaiv cov nroj tsuag tshwj xeeb. No qhia hauv ib tsab xov xwm luam tawm nyob rau hauv phau ntawv journal Kev Loj Hlob & Sib Txawv Txij Nkawm.
Kev tsim kho ntawm RNAi-based thev naus laus zis tuaj yeem siv rau cov tswv yim tswj kev tua kab.
Qhov kev hloov pauv ntawm "caj npab haiv neeg" yog coj los ntawm pathogens thiab lawv cov neeg raug tsim txom, uas ua rau muaj kev tawm tsam tshwj xeeb ntawm kev tiv thaiv thiab kev tawm tsam. Yog li, parasitic fungi pathogenic rau kab yog siv los tiv thaiv kev ua liaj ua teb cov qoob loo tiv thaiv cov kab tsuag. Cov nceb no tuaj yeem siv cov enzymes tshwj xeeb, xws li cov protease-tawg proteins, txhawm rau nkag mus rau ntawm qhov sib xyaw ntawm lub cev. Txawm li cas los xij, qee cov kab, suav nrog cov kab npauj loj (Galleria mellonella), tso tawm cov protease inhibitors thiab lwm yam kev tiv thaiv kab mob los tiv thaiv kev tawm tsam fungal.
Txog rau hnub tim, tsis muaj cov pov thawj molecular rau qhov ua tsis tau lub luag haujlwm ntawm cov kab mob metalloproteinase tiv thaiv kab mob rau hauv cov tshuaj tiv thaiv kev tiv thaiv. Txhawm rau kom paub tseeb tias qhov sib txuas ntawm cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob rau cov hu ua fungi, cov kws tshawb fawb tau siv cov qauv ntawm RNA cuam tshuam, uas muaj nyob rau hauv kev xaiv hluav Cov kws tshawb nrhiav tau thaiv qhov kev txiav txim siab ntawm metalloproteinase inhibitor (IMPI) hauv Galleria mellonella thiab tom qab ntawd nthuav tawm cov kab rau cov kab mob entomopathogenic fungus Metarhizium brunneum.
Cov qib IMPI tau txo qis hauv kev sib xyaw ua ke (kaum tawm) thiab adipose lub cev (tsib zaug) ntawm RNA-kho kab tsuag piv rau kev tswj cov kab menyuam, thiab lub neej no muaj ntau dua. Yog li, thaiv IMPI los ntawm RNA cuam tshuam ua kom muaj kev tiv thaiv tus kab mob tiv thaiv thiab ua rau cov kab ua rau muaj kab mob kis tau yooj yim.
